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The section you selected contains information intended for U.S. healthcare professionals only. Please certify that you are a U.S. healthcare professional by clicking the link below.

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Your healthcare provider may refer to your depression as “major depressive disorder” or “MDD.”

Actor portrayal

Major depressive disorder is a serious medical illness affecting an estimated 15 million American adults. For many, their antidepressant may not be working well enough. A large study showed that 2 out of 3 people taking an antidepressant still experienced symptoms of depression.

Use the tools below and have a discussion with your doctor.

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It’s important to know that antidepressants may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment. Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings and report such changes to the healthcare provider.

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Symptoms of depression may last for 2 weeks or more, occurring nearly every day, and may include:

If you’ve been on an antidepressant for at least 8 weeks and still dealing with symptoms of depression, talk to your healthcare provider to see if adding REXULTI ® (brexpiprazole) may be an option for you.

If you are commercially-insured, you may be eligible for the REXULTI Savings Card*
Open for Savings *This program is not health insurance. Further conditions apply.
Adding REXULTI (brexpiprazole) may help with your unresolved symptoms
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INDICATION and IMPORTANT SAFETY INFORMATION for REXULTI ® (brexpiprazole)

INDICATION: REXULTI is a prescription medicine used to treat:

It is not known if REXULTI is safe and effective in people under 18 years of age.

IMPORTANT SAFETY INFORMATION:

Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of patients with dementia-related psychosis.

Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment. Depression and other serious mental illnesses are the most important causes of suicidal thoughts or actions. Some people may have a particularly high risk of having suicidal thoughts or actions. Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed. Report any changes in these symptoms immediately to the doctor. REXULTI is not approved for the treatment of people younger than 18 years of age.

Do not take REXULTI if you are allergic to brexpiprazole or any of the ingredients in REXULTI. Allergic reactions have included rash, facial swelling, hives and itching, and anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the mouth, face, lips, or tongue.

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